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Chiral synthesis of LSD1 inhibitor GSK2879552 enabled by directed evolution of an imine reductase

Imine reductases have been regarded as one of the most promising enzymes by the pharmaceutical industry—but their industrial application is still lacking. This work reports the successful industrial application of an imine reductase, enabled by directed evolution.

Markus Schober
Chris MacDermaid
Gheorghe-Doru Roiban
Research16 Sept 2019
Nature Catalysis

Volume: 2, P: 909-915

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Chiral synthesis of LSD1 inhibitor GSK2879552 enabled by directed evolution of an imine reductase

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