Nature Search

SNARE motif and neurotoxins

Ornella Rossetto
Giampietro Schiavo
Clifford C. Shone
Research01 Dec 1994
Nature

Volume: 372, P: 415-416
Neurotransmission and secretion

Tomaso Patarnello
Luca Bargelloni
Cesare Montecucco
Research12 Aug 1993
Nature

Volume: 364, P: 581-582
Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin

Giampietro G. Schiavo
Fabio Benfenati
Cesare Montecucco
Research29 Oct 1992
Nature

Volume: 359, P: 832-835
A possible docking and fusion particle for synaptic transmission

Giampietro Schiavo
Michael J. S. Gmachl
James E. Rothman
Research14 Dec 1995
Nature

Volume: 378, P: 733-736
An NSF function distinct from ATPase-dependent SNARE disassembly is essential for Golgi membrane fusion

Joyce M. M. Müller
Catherine Rabouille
David T. Shima
Research02 Sept 1999
Nature Cell Biology

Volume: 1, P: 335-340
Alternative energy for neuronal motors

Neurons use molecular motors to power the transport of cargoes along their axonal extensions. Fresh evidence challenges the view that cellular organelles called mitochondria are the main energy providers for this process.

Giampietro Schiavo
Mike Fainzilber
News & Views13 Mar 2013
Nature

Volume: 495, P: 178-179
A hitchhiker's guide to the nervous system: the complex journey of viruses and toxins

To circumvent the blood–brain barrier and invade the central nervous system, many pathogens enter neurons at the nerve terminal and travel the length of the axon to reach the cell body. Here, Kremer and colleagues review the neuronal trafficking pathways that are subverted by neurotropic viruses and toxins.

Sara Salinas
Giampietro Schiavo
Eric J. Kremer
Reviews01 Sept 2010
Nature Reviews Microbiology

Volume: 8, P: 645-655
Dangerous liaisons on neurons

Crystal structures show that botulinum toxins bind simultaneously to two sites on neurons. This dual interaction allows them to use a Trojan-horse strategy to enter nerve terminals, with deadly effect.

Giampietro Schiavo
News & Views13 Dec 2006
Nature

Volume: 444, P: 1019-1020
The bacterial toxin toolkit

Giampietro Schiavo
F. Gisou van der Goot
Reviews01 Jul 2001
Nature Reviews Molecular Cell Biology

Volume: 2, P: 530-537
Axonal transport and neurological disease

Axonal transport is the process whereby motor proteins navigate microtubules to deliver diverse cargoes from one end of the axon to the other. In this Review, Schiavo and colleagues explore the link between perturbations in axonal transport and neurological disease.

James N. Sleigh
Alexander M. Rossor
Giampietro Schiavo
Reviews26 Sept 2019
Nature Reviews Neurology

Volume: 15, P: 691-703
Author Correction: TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A

Anna-Leigh Brown
Oscar G. Wilkins
Pietro Fratta
Amendments and CorrectionsOpen Access18 Jun 2024
Nature

Volume: 631, P: E7
TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A

Risk variants for ALS and FTD in the synaptic gene UNC13A increase the expression of an UNC13A cryptic exon in neurons with TDP-43 depletion.

Anna-Leigh Brown
Oscar G. Wilkins
Pietro Fratta
ResearchOpen Access23 Feb 2022
Nature

Volume: 603, P: 131-137
A handle on NSF

David J. Owen
Giampietro Schiavo
News & Views01 Sept 1999
Nature Cell Biology

Volume: 1, P: E127-E128
Kidins220 deficiency causes ventriculomegaly via SNX27-retromer-dependent AQP4 degradation

Ana del Puerto
Julia Pose-Utrilla
Teresa Iglesias
ResearchOpen Access17 May 2021
Molecular Psychiatry

Volume: 26, P: 6411-6426
A neuroprotective astrocyte state is induced by neuronal signal EphB1 but fails in ALS models

Astrocytes can have protective or detrimental effects on neurons during injury, but the molecular mechanisms that determine these different states are unresolved. Here the authors identify a pathway via neuronal EphB1 that induces neuroprotective signalling in astrocytes through ephrin-B1 mediated STAT3 activation, which is impaired in models of amyotrophic lateral sclerosis.

Giulia E. Tyzack
Claire E. Hall
András Lakatos
ResearchOpen Access27 Oct 2017
Nature Communications

Volume: 8, P: 1-17
Bimodal regulation of axonal transport by the GDNF-RET signalling axis in healthy and diseased motor neurons

Elena R. Rhymes
Andrew P. Tosolini
Giampietro Schiavo
ResearchOpen Access07 Jul 2022
Cell Death & Disease

Volume: 13, P: 1-11
Inhibiting p38 MAPK alpha rescues axonal retrograde transport defects in a mouse model of ALS

Katherine L. Gibbs
Bernadett Kalmar
Giampietro Schiavo
ResearchOpen Access22 May 2018
Cell Death & Disease

Volume: 9, P: 1-16
Neuropilin 1 sequestration by neuropathogenic mutant glycyl-tRNA synthetase is permissive to vascular homeostasis

James N. Sleigh
Adriana Gómez-Martín
Giampietro Schiavo
ResearchOpen Access23 Aug 2017
Scientific Reports

Volume: 7, P: 1-11
Kidins220 sets the threshold for survival of neural stem cells and progenitors to sustain adult neurogenesis

Ana del Puerto
Coral Lopez-Fonseca
Eva Porlan
ResearchOpen Access04 Aug 2023
Cell Death & Disease

Volume: 14, P: 1-17
NMJ-Analyser identifies subtle early changes in mouse models of neuromuscular disease

Alan Mejia Maza
Seth Jarvis
Carole H. Sudre
ResearchOpen Access10 Jun 2021
Scientific Reports

Volume: 11, P: 1-17
Retrograde transport of Akt by a neuronal Rab5-APPL1 endosome

Livia Goto-Silva
Marisa P. McShane
Marino Zerial
ResearchOpen Access21 Feb 2019
Scientific Reports

Volume: 9, P: 1-14
Developmental demands contribute to early neuromuscular degeneration in CMT2D mice

James N. Sleigh
Aleksandra M. Mech
Giampietro Schiavo
ResearchOpen Access23 Jul 2020
Cell Death & Disease

Volume: 11, P: 1-10

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