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The characterization of variable new antigen receptors targeting FAP isolated from a novel immunized library

Through the direct immunization of a nurse shark, we identified a suite of VNAR domains that were effective at targeting FAP.

Gihan S. Gunaratne
Joseph P. Gallant
Aaron M. LeBeau
ResearchOpen Access13 Aug 2025
Communications Biology

Volume: 8, P: 1-17
Mechanisms of SARS-CoV-2 neutralization by shark variable new antigen receptors elucidated through X-ray crystallography

Shark antibodies (Variable New Antigen Receptors, VNARs) are the smallest naturally occurring antibody fragments. Here, the authors screen a VNAR phage display library against the SARS-CoV2 receptor binding domain (RBD) and identify VNARs that neutralize the SARSCoV-2 virus and discuss their mechanisms of viral neutralization.

Obinna C. Ubah
Eric W. Lake
Caroline J. Barelle
ResearchOpen Access16 Dec 2021
Nature Communications

Volume: 12, P: 1-12
TMEM33 regulates intracellular calcium homeostasis in renal tubular epithelial cells

Polycystin-2 (PC2) is an ion channel commonly found mutated in autosomal dominant polycystic kidney disease. Here Arhatte et al. identify transmembrane protein 33 (TMEM33) as a regulator of PC2 function at the endoplasmic reticulum, and find that deletion of TMEM33 protects mice from acute kidney injury.

Malika Arhatte
Gihan S. Gunaratne
Amanda Patel
ResearchOpen Access02 May 2019
Nature Communications

Volume: 10, P: 1-16
The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand

Schistosomiasis is caused by infection with the flatworm Schistosoma, and praziquantel is the drug of choice for its treatment. Here, Chan and colleagues identify praziquantel as a ligand for the human serotoninergic 5-HT_2B G-protein-coupled receptor, and reveal a function for praziquantel as a regulator of vascular tone in treated hosts.

John D. Chan
Pauline M. Cupit
Jonathan S. Marchant
ResearchOpen Access05 Dec 2017
Nature Communications

Volume: 8, P: 1-7

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The characterization of variable new antigen receptors targeting FAP isolated from a novel immunized library

Mechanisms of SARS-CoV-2 neutralization by shark variable new antigen receptors elucidated through X-ray crystallography

TMEM33 regulates intracellular calcium homeostasis in renal tubular epithelial cells

The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand

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