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Showing 1–3 of 3 results
Advanced filters: Author: Giichi Takaesu Clear advanced filters

  • The ATG12~ATG5 conjugate promotes the transfer of the ubiquitin-like protein LC3 to phosphatidylethanolamine (PE), a modification required for autophagosome formation. Structural and biochemical analyses reveal the determinants for ATG12~ATG5 binding to ATG16 and the E3 ligase ATG3, and indicate how the conjugate stimulates PE–LC3 formation.

    • Chinatsu Otomo
    • Zoltan Metlagel
    • Takanori Otomo
    Research
    Nature Structural & Molecular Biology
    Volume: 20, P: 59-66

  • Suppressor of cytokine signaling 1 has been linked to the negative regulation of Toll-like receptor signaling. The mechanism for this seems to be suppressor of cytokine signaling 1–mediated degradation of the adaptor Mal, which is required for Toll-like receptor signaling.

    • Takashi Kobayashi
    • Giichi Takaesu
    • Akihiko Yoshimura
    News & Views
    Nature Immunology
    Volume: 7, P: 123-124