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Showing 1–3 of 3 results
Advanced filters: Author: Gillian Lamont Clear advanced filters

  • DNA-dependent protein kinase (DNA-PK) plays a major role in the DNA damage response upon double-strand break formation. Here, the authors show that the DNA-PK inhibitor AZD7648, enhances the activity of radiotherapy, chemotherapy and the PARP inhibitor olaparib in multiple mouse tumour models.

    • Jacqueline H. L. Fok
    • Antonio Ramos-Montoya
    • Elaine B. Cadogan
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • An orally available VHL-ERα PROTAC was developed that showed excellent degradation in vitro. When dosing in vivo, the degradation of ERα was lower than expected, due to competitive binding at the ERα binding site between the PROTAC and a linker metabolite.

    • Thomas G. Hayhow
    • Beth Williamson
    • Claire Crafter
    ResearchOpen Access
    Communications Biology
    Volume: 7, P: 1-17

  • The Summer North Atlantic Oscillation responds sensitively to an anomalous strength of the stratospheric polar vortex in spring, which can be exploited for seasonal predictions, according to large-ensemble climate prediction and perturbation experiments.

    • Nick Dunstone
    • Doug M. Smith
    • Lei Wang
    ResearchOpen Access
    Communications Earth & Environment
    Volume: 4, P: 1-11