Exosomes are increasingly recognized as key intermediaries of intercellular communication, yet the mechanisms governing their biogenesis remain unclear. Zimmermann, David and colleagues report that interactions between the transmembrane protein syndecan, its associated protein syntenin and the ESCRT adaptor ALIX are necessary for exosome formation, supporting a role for the ESCRT machinery in this process.
- Maria Francesca Baietti
- Zhe Zhang
- Guido David
