Bouyer et al. report that the new permeation pathways (NPP), responsible of modulating erythrocyte permeability to diverse solutes and considered only to be in pathogenic asexual stages of P. falciparum, are also active in erythrocytes infected with immature gametocytes and this activity declines with gametocyte maturation. NPPs are regulated by the cAMP signalling cascade, and the decrease in cAMP levels in mature stages slows NPP activity.
- Guillaume Bouyer
- Daniela Barbieri
- Catherine Lavazec
