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Showing 1–2 of 2 results
Advanced filters: Author: Giuseppina Claps Clear advanced filters

  • The absence of scaffold protein Ambra1 leads to hyperproliferation and growth in mouse models. Here the authors show that Ambra1 deficiency accelerates melanoma growth and increases metastasis in mouse models of melanoma through FAK1 hyperactivation.

    • Luca Di Leo
    • Valérie Bodemeyer
    • Francesco Cecconi
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17

  • A high serum lactate dehydrogenase (LDH) level is generally associated with an inferior outcome in patients with most tumour types. LDH is also known to have immunosuppressive and/or tumour-promoting effects, suggesting a potentially broader role for this enzyme in clinical oncology. In this Review, the authors provide a holistic overview of the current role of LDH in both cancer biology and oncology, and highlight possible areas of future research interest, including the development of novel therapies targeting LDH.

    • Giuseppina Claps
    • Sara Faouzi
    • Caroline Robert
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 19, P: 749-762