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Showing 1–3 of 3 results
Advanced filters: Author: Giusi Moffa Clear advanced filters

  • Activating mutations in the Wnt signalling pathway are associated with colon cancer. Here the authors show that tumour cells carrying mutations in APC and β-catenin are still regulated by Wnt ligands, suggesting that Wnt secretion and receptor signalling remains important to control downstream signalling.

    • Oksana Voloshanenko
    • Gerrit Erdmann
    • Michael Boutros
    ResearchOpen Access
    Nature Communications
    Volume: 4, P: 1-13

  • Tumour heterogeneity hinders translation of large-scale genomic data into the clinic. Here the authors develop a method for the stratification of cancer patients based on the molecular gene status, including genetic interactions, rather than clinico-histological data, and apply it to TCGA data for over 8000 cases across 22 cancer types.

    • Jack Kuipers
    • Thomas Thurnherr
    • Niko Beerenwinkel
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10