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Showing 1–4 of 4 results
Advanced filters: Author: Giusy Di Conza Clear advanced filters

  • Tumor-associated macrophages support an immunosuppressive tumor microenvironment. Di Conza et al. uncover how IRE1–XBP1 and IRE1−STAT3 endoplasmic reticulum stress responses pathways are engaged by tumor-derived lipids to orchestrate pro-tumorigenic features and survival in tumor-associated macrophages.

    • Giusy Di Conza
    • Chin-Hsien Tsai
    • Ping-Chih Ho
    Research
    Nature Immunology
    Volume: 22, P: 1403-1415

  • Whether neutrophils exert an anti- or pro-tumorigenic function has remained controversial; now, expression of the receptor molecule MET in neutrophils is shown to be required for their ability to restrict tumour growth in several mouse cancer models, with potential implications for human cancer therapy.

    • Veronica Finisguerra
    • Giusy Di Conza
    • Massimiliano Mazzone
    Research
    Nature
    Volume: 522, P: 349-353

  • Activation of the unfolded protein response during immune cell activation has emerged as making an essential contribution to the response to infection and inflammation. In this Review, the authors discuss where, how and when a disbalanced unfolded protein response can become pathological and thus a potential therapeutic target.

    • Giusy Di Conza
    • Ping-Chih Ho
    • Stanley Ching-Cheng Huang
    Reviews
    Nature Reviews Immunology
    Volume: 23, P: 546-562