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Showing 1–2 of 2 results
Advanced filters: Author: Gizem Günes Günsel Clear advanced filters

  • Chronic obstructive pulmonary disease is a progressive and incurable chronic condition that involves accumulation of inflammatory macrophages in the lung tissue. Authors here show in mouse models of lung disease that PRMT7, a protein arginine methyltransferase, is an important regulator of recruitment and the pro-inflammatory phenotype of macrophages.

    • Gizem Günes Günsel
    • Thomas M. Conlon
    • Ali Önder Yildirim
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-21

  • Excess macrophage elastase MMP-12 is a major driver of chronic obstructive pulmonary disease. Here the authors show that the endolysosomal ion channel TRPML3 is a regulator of the cellular reuptake of MMP-12, thus neutralizing harmful MMP-12 in the lung.

    • Barbara Spix
    • Elisabeth S. Butz
    • Christian Grimm
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-18