Nature Search

Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
Integrated exome and RNA sequencing of dedifferentiated liposarcoma

Understanding the genomic features of dedifferentiated liposarcoma (DDLPS) is likely to uncover new options for management. Here, the authors reveal three prognostic groups, and highlight molecular markers associated with malignant transformation.

Makoto Hirata
Naofumi Asano
Koichi Matsuda
ResearchOpen Access12 Dec 2019
Nature Communications

Volume: 10, P: 1-12
Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer

Hidewaki Nakagawa and colleagues report a comprehensive genome-wide mutational landscape of 300 liver cancers from Japanese individuals. They identify candidate driver mutations, including ones in noncoding regions, and structural mutations affecting the expression of nearby genes.

Akihiro Fujimoto
Mayuko Furuta
Hidewaki Nakagawa
Research11 Apr 2016
Nature Genetics

Volume: 48, P: 500-509
Defect passivation in methylammonium/bromine free inverted perovskite solar cells using charge-modulated molecular bonding

Molecular passivation is promising for improving the performance and operation stability of perovskite solar cells. Here, authors employ piperazine dihydriodide to strengthen adhesion to MA-free perovskite via −NH₂I and Mulliken charge distribution, realizing charge-regulated molecular passivation.

Dhruba B. Khadka
Yasuhiro Shirai
Kenjiro Miyano
ResearchOpen Access29 Jan 2024
Nature Communications

Volume: 15, P: 1-16
Replication stress triggers microsatellite destabilization and hypermutation leading to clonal expansion in vitro

Mismatch repair (MMR)-deficient cancers are characterized by microsatellite instability (MSI) and hypermutation. Here authors reveal a mechanism by which replication stress induces MSI and associated induction of mutations in vitro.

Yusuke Matsuno
Yuko Atsumi
Ken-ichi Yoshioka
ResearchOpen Access02 Sept 2019
Nature Communications

Volume: 10, P: 1-13
A Japanese prospective multicenter study of urinary oxysterols in biliary atresia

Ken-ichiro Konishi
Tatsuki Mizuochi
Akihiko Kimura
ResearchOpen Access02 Mar 2021
Scientific Reports

Volume: 11, P: 1-8
Publisher Correction: Integrated exome and RNA sequencing of dedifferentiated liposarcoma

Makoto Hirata
Naofumi Asano
Koichi Matsuda
Amendments and CorrectionsOpen Access19 Feb 2020
Nature Communications

Volume: 11, P: 1
Enhancing the regulatory function of the autonomic nervous system using sounds with inaudible high-frequency components

Koto Jogasaki
Norie Kawai
Manabu Honda
ResearchOpen Access23 Jul 2025
Scientific Reports

Volume: 15, P: 1-11
Synchronously wired infrared antennas for resonant single-quantum-well photodetection up to room temperature

Applications of metasurfaces for optoelectronic devices require wiring to each isolated antenna for biasing and current flow. Here, the authors report optimal wire interconnects design for controlling the optical properties and present antenna-enhanced mid-infrared photodetection incorporating a single quantum well.

Hideki T. Miyazaki
Takaaki Mano
Hiroshi Miyazaki
ResearchOpen Access28 Jan 2020
Nature Communications

Volume: 11, P: 1-10
Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators

Hidewaki Nakagawa and colleagues report the whole-genome sequencing of 27 hepatocellular carcinomas. They find that chromatin regulators were mutated in approximately 50% of tumors.

Akihiro Fujimoto
Yasushi Totoki
Hidewaki Nakagawa
Research27 May 2012
Nature Genetics

Volume: 44, P: 760-764
Dynamics of microbial communities on the corrosion behavior of steel in freshwater environment

Satoshi Wakai
Nanami Eno
Yasuyuki Miyano
ResearchOpen Access04 Jun 2022
npj Materials Degradation

Volume: 6, P: 1-11
The Japanese herbal medicine Hangeshashinto enhances oral keratinocyte migration to facilitate healing of chemotherapy-induced oral ulcerative mucositis

Kanako Miyano
Moeko Eto
Yasuhito Uezono
ResearchOpen Access17 Jan 2020
Scientific Reports

Volume: 10, P: 1-13
Author Correction: The Japanese herbal medicine Hangeshashinto enhances oral keratinocyte migration to facilitate healing of chemotherapy-induced oral ulcerative mucositis

Kanako Miyano
Moeko Eto
Yasuhito Uezono
Amendments and CorrectionsOpen Access09 Nov 2020
Scientific Reports

Volume: 10, P: 1-2

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