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Showing 1–8 of 8 results
Advanced filters: Author: Goedele N Maertens Clear advanced filters

  • Insertion of retrovirus genome into host genome to replicate is mediated by a tetramer of the virus-encoded integrase protein. The structure of a related integrase from prototype foamy virus bound to the cleaved viral DNA ends, a complex called the intasome, was previously revealed. These authors solve the structure of the intasome interacting with the target host DNA both before and after it is cleaved, revealing new details of the integration process that may help in designing improved inhibitors of HIV.

    • Goedele N. Maertens
    • Stephen Hare
    • Peter Cherepanov
    Research
    Nature
    Volume: 468, P: 326-329

  • A hallmark of retroviral replication is establishment of the proviral state, wherein a DNA copy of the viral RNA genome is stably incorporated into a host cell chromosome by the viral enzyme integrase. In this Review, Maertens, Engelman and Cherepanov explore the structure and function of retroviral integrase and how this knowledge is informing the development of integrase inhibitors for the treatment of HIV infection.

    • Goedele N. Maertens
    • Alan N. Engelman
    • Peter Cherepanov
    Reviews
    Nature Reviews Microbiology
    Volume: 20, P: 20-34

  • Evidence has indicated that non-coding RNAs are involved in gene repression by Polycomb complexes. MOV10, a putative RNA helicase, is now found to be associated with a human Polycomb protein and linked to Polycomb-mediated repression of the INK4a tumor suppressor, suggesting a role for RNA helicase activity in the silencing mechanism.

    • Selma El Messaoudi-Aubert
    • James Nicholls
    • Gordon Peters
    Research
    Nature Structural & Molecular Biology
    Volume: 17, P: 862-868

  • Palindromic nucleotide sequences are not present at individual integration sites for the retroviruses HTLV-1 and HIV-1, but arise in the population average owing to a non-palindromic motif found in roughly equal proportions on the plus and minus strands.

    • Paul D. W. Kirk
    • Maxime Huvet
    • Charles R. M. Bangham
    Research
    Nature Microbiology
    Volume: 2, P: 1-6