Nature Search

Hundreds of dual-stage antimalarial molecules discovered by a functional gametocyte screen

There is a need forPlasmodium transmission blocking drugs for malaria elimination. Here, Miguel-Blanco et al. screen >10,000 compounds against stage V female gametocytes, identify active compounds belonging to 57 chemotypes and confirm transmission blocking activity of four selected compounds in vitro.

Celia Miguel-Blanco
Irene Molina
Esperanza Herreros
ResearchOpen Access17 May 2017
Nature Communications

Volume: 8, P: 1-10
Fatty acids homeostasis during fasting predicts protection from chemotherapy toxicity

Fasting has been reported to protect from chemotherapy-associated toxicity. Here, the authors show that fatty acid profiles in erythrocyte membranes and gene expression from peripheral blood mononuclear cells are associated to the fasting-mediated benefits during cancer treatment in mice and patients.

Marta Barradas
Adrián Plaza
Pablo J. Fernandez-Marcos
ResearchOpen Access27 Sept 2022
Nature Communications

Volume: 13, P: 1-22
The first wave of the COVID-19 epidemic in Spain was associated with early introductions and fast spread of a dominating genetic variant

Analysis of 2,170 SARS-CoV-2 sequences from the first wave of the COVID-19 epidemic in Spain provides insights into transmission patterns and the effects of lockdown on the emergence of new variants.

Mariana G. López
Álvaro Chiner-Oms
Iñaki Comas
Research30 Sept 2021
Nature Genetics

Volume: 53, P: 1405-1414
Potential protective effect against SARS-CoV-2 infection by APOE rs7412 polymorphism

Isabel Espinosa-Salinas
Gonzalo Colmenarejo
Ana Ramírez de Molina
ResearchOpen Access04 May 2022
Scientific Reports

Volume: 12, P: 1-11
Ranking of a wide multidomain set of predictor variables of children obesity by machine learning variable importance techniques

Helena Marcos-Pasero
Gonzalo Colmenarejo
Viviana Loria-Kohen
ResearchOpen Access21 Jan 2021
Scientific Reports

Volume: 11, P: 1-14
Genetic Polymorphisms, Mediterranean Diet and Microbiota-Associated Urolithin Metabotypes can Predict Obesity in Childhood-Adolescence

Adrián Cortés-Martín
Gonzalo Colmenarejo
Juan Carlos Espín
ResearchOpen Access12 May 2020
Scientific Reports

Volume: 10, P: 1-13
Identifying inhibitors of the Leishmania inositol phosphorylceramide synthase with antiprotozoal activity using a yeast-based assay and ultra-high throughput screening platform

Jennifer L. Norcliffe
John G. Mina
Paul W. Denny
ResearchOpen Access02 Mar 2018
Scientific Reports

Volume: 8, P: 1-10
Physical fitness and physical activity association with cognitive function and quality of life: baseline cross-sectional analysis of the PREDIMED-Plus trial

Lidia Daimiel
Miguel A. Martínez-González
José M. Ordovás
ResearchOpen Access26 Feb 2020
Scientific Reports

Volume: 10, P: 1-12
Predicting transmission blocking potential of anti-malarial compounds in the Mosquito Feeding Assay using Plasmodium falciparum Male Gamete Inhibition Assay

Gonzalo Colmenarejo
Sonia Lozano
Janneth Rodrigues
ResearchOpen Access17 May 2018
Scientific Reports

Volume: 8, P: 1-13
New Compound Sets Identified from High Throughput Phenotypic Screening Against Three Kinetoplastid Parasites: An Open Resource

Imanol Peña
M. Pilar Manzano
J. Julio Martin
ResearchOpen Access05 Mar 2015
Scientific Reports

Volume: 5, P: 1-12

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Hundreds of dual-stage antimalarial molecules discovered by a functional gametocyte screen

Fatty acids homeostasis during fasting predicts protection from chemotherapy toxicity

The first wave of the COVID-19 epidemic in Spain was associated with early introductions and fast spread of a dominating genetic variant

Potential protective effect against SARS-CoV-2 infection by APOE rs7412 polymorphism

Ranking of a wide multidomain set of predictor variables of children obesity by machine learning variable importance techniques

Genetic Polymorphisms, Mediterranean Diet and Microbiota-Associated Urolithin Metabotypes can Predict Obesity in Childhood-Adolescence

Identifying inhibitors of the Leishmania inositol phosphorylceramide synthase with antiprotozoal activity using a yeast-based assay and ultra-high throughput screening platform

Physical fitness and physical activity association with cognitive function and quality of life: baseline cross-sectional analysis of the PREDIMED-Plus trial

Predicting transmission blocking potential of anti-malarial compounds in the Mosquito Feeding Assay using Plasmodium falciparum Male Gamete Inhibition Assay

New Compound Sets Identified from High Throughput Phenotypic Screening Against Three Kinetoplastid Parasites: An Open Resource

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