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Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription

María Guillamot
Eusebio Manchado
Marcos Malumbres
ResearchOpen Access12 Dec 2011
Scientific Reports

Volume: 1, P: 1-7
Midkine rewires the melanoma microenvironment toward a tolerogenic and immune-resistant state

Tumor-secreted midkine modulates immune tolerance in the melanoma tumor microenvironment and determines resistance to immune checkpoint blockade.

Daniela Cerezo-Wallis
Marta Contreras-Alcalde
María S. Soengas
Research19 Oct 2020
Nature Medicine

Volume: 26, P: 1865-1877
Distinct roles of cohesin-SA1 and cohesin-SA2 in 3D chromosome organization

Depletion, ChIP and Hi-C analyses of the genomic distribution of the two variant cohesin complexes in human cells reveal non-redundant functions and differential contributions to 3D genome organization.

Aleksandar Kojic
Ana Cuadrado
Ana Losada
Research04 Jun 2018
Nature Structural & Molecular Biology

Volume: 25, P: 496-504
Lineage-specific roles of the cytoplasmic polyadenylation factor CPEB4 in the regulation of melanoma drivers

Cytoplasmic polyadenylated transcripts have been poorly characterized, particularly in cancer. Here the authors identify a lineage-specific requirement of the cytoplasmic polyadenylation binding protein 4 (CPEB4) in malignant melanoma and show that it controls melanoma drivers MITF and RAB27A.

Eva Pérez-Guijarro
Panagiotis Karras
María S. Soengas
ResearchOpen Access18 Nov 2016
Nature Communications

Volume: 7, P: 1-17
Lineage-restricted function of the pluripotency factor NANOG in stratified epithelia

The transcription factor Nanog regulates self-renewal in pluripotent stem cells and cancer stem cells. Here the authors show that Nanog is expressed in mouse adult stratified epithelia, and its overexpression increases proliferation and aneuploidy and activates pathways associated to mitosis.

Daniela Piazzolla
Adelaida R. Palla
Manuel Serrano
Research30 Jun 2014
Nature Communications

Volume: 5, P: 1-14
In vivo phosphoproteomics reveals kinase activity profiles that predict treatment outcome in triple-negative breast cancer

Triple-negative breast cancer (TNBC) lacks prognostic and predictive markers. Here, the authors use phosphoproteomics to define kinases with distinct activity profiles in TNBC, demonstrating their prognostic value as well as their utility for simplifying TNBC classification and designing drug regimens.

Ivana Zagorac
Sara Fernandez-Gaitero
Miguel Quintela-Fandino
ResearchOpen Access29 Aug 2018
Nature Communications

Volume: 9, P: 1-15
Systems analysis identifies melanoma-enriched pro-oncogenic networks controlled by the RNA binding protein CELF1

Hundreds of mRNA binding proteins (mRBPs) have been described in mammalian cells. Here, the authors identify RBPs differentially regulated in melanoma, and show the RBP CELF1 controlling a distinct set of protumorigenic factors.

Metehan Cifdaloz
Lisa Osterloh
María S. Soengas
ResearchOpen Access21 Dec 2017
Nature Communications

Volume: 8, P: 1-18
Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites

The shelterin complex binds and protects mammalian telomeres. The shelterin component, Rap1, binds to non-telomeric regions and has extra-telomeric functions in transcriptional gene regulation.

Paula Martinez
Maria Thanasoula
Maria A. Blasco
Research11 Jul 2010
Nature Cell Biology

Volume: 12, P: 768-780
Combined inhibition of DDR1 and Notch signaling is a therapeutic strategy for KRAS-driven lung adenocarcinoma

Transcriptional profiling of Kras-driven early lesions—aimed at identifying founder events—reveals DDR1 as a therapeutic target relevant to adenocarcinoma.

Chiara Ambrogio
Gonzalo Gómez-López
Mariano Barbacid
Research08 Feb 2016
Nature Medicine

Volume: 22, P: 270-277
A Braf kinase-inactive mutant induces lung adenocarcinoma

Kinase-inactive Braf mutants can initiate the development of lung adenocarcinoma in mice; co-expression of activated Kras enhances tumour initiation and progression, and wild-type Braf is required to sustain tumorigenesis.

Patricia Nieto
Chiara Ambrogio
David Santamaría
Research02 Aug 2017
Nature

Volume: 548, P: 239-243
An in silico analysis identifies drugs potentially modulating the cytokine storm triggered by SARS-CoV-2 infection

Laura Sanchez-Burgos
Gonzalo Gómez-López
Oscar Fernandez-Capetillo
ResearchOpen Access31 Jan 2022
Scientific Reports

Volume: 12, P: 1-10
Mitochondrial RNA methyltransferase TRMT61B is a new, potential biomarker and therapeutic target for highly aneuploid cancers

Alberto Martín
Carolina Epifano
Ignacio Pérez de Castro
Research22 Jul 2022
Cell Death & Differentiation

Volume: 30, P: 37-53
MEK inhibition enhances the response to tyrosine kinase inhibitors in acute myeloid leukemia

María Luz Morales
Alicia Arenas
Joaquín Martínez-López
ResearchOpen Access09 Dec 2019
Scientific Reports

Volume: 9, P: 1-11
The pluripotency factor NANOG promotes the formation of squamous cell carcinomas

Adelaida R. Palla
Daniela Piazzolla
Manuel Serrano
ResearchOpen Access19 May 2015
Scientific Reports

Volume: 5, P: 1-13
p21^Cip1 plays a critical role in the physiological adaptation to fasting through activation of PPARα

Elena Lopez-Guadamillas
Pablo J. Fernandez-Marcos
Manuel Serrano
ResearchOpen Access10 Oct 2016
Scientific Reports

Volume: 6, P: 1-10

Search

Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription

Midkine rewires the melanoma microenvironment toward a tolerogenic and immune-resistant state

Distinct roles of cohesin-SA1 and cohesin-SA2 in 3D chromosome organization

Lineage-specific roles of the cytoplasmic polyadenylation factor CPEB4 in the regulation of melanoma drivers

Lineage-restricted function of the pluripotency factor NANOG in stratified epithelia

In vivo phosphoproteomics reveals kinase activity profiles that predict treatment outcome in triple-negative breast cancer

Systems analysis identifies melanoma-enriched pro-oncogenic networks controlled by the RNA binding protein CELF1

Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites

Combined inhibition of DDR1 and Notch signaling is a therapeutic strategy for KRAS-driven lung adenocarcinoma

A Braf kinase-inactive mutant induces lung adenocarcinoma

An in silico analysis identifies drugs potentially modulating the cytokine storm triggered by SARS-CoV-2 infection

Mitochondrial RNA methyltransferase TRMT61B is a new, potential biomarker and therapeutic target for highly aneuploid cancers

MEK inhibition enhances the response to tyrosine kinase inhibitors in acute myeloid leukemia

The pluripotency factor NANOG promotes the formation of squamous cell carcinomas

p21^Cip1 plays a critical role in the physiological adaptation to fasting through activation of PPARα

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