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Showing 1–8 of 8 results
Advanced filters: Author: Gordon H. Guyatt Clear advanced filters

  • Many survivors of COVID-19 experience persistent symptoms, continuing beyond three months from the onset of infection. In this study, authors investigate the effect of remdesivir on recovery and long-COVID-19 symptoms, as well as quality of life and other symptom outcomes, in the 1-year follow-up of a randomised trial.

    • Olli P. O. Nevalainen
    • Saana Horstia
    • Kari A. O. Tikkinen
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-6

  • Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

    • Athanasios Kousathanas
    • Erola Pairo-Castineira
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 607, P: 97-103

  • Any worthwhile guideline must be evidence-based, or should it? Evidence for the construction of guidelines often comes from clinical trials that are performed in the West according to the priorities and goals of that population and those of the pharmaceutical industry whose resources are relied upon to perform such trials. This Viewpoint article discusses the development of guidelines using an evidence-based approach and whether this approach is applicable worldwide.

    • M Fried
    • EMM Quigley
    • R Horton
    Reviews
    Nature Clinical Practice Gastroenterology & Hepatology
    Volume: 5, P: 60-61

  • Clinical Guidelines are primarily developed in the affluent West. This Viewpoint article discusses whether these guidelines are really useful and relevant to resource-poor, developing countries, and whether attempts to adhere to such guidelines obscure more fundamental issues such as the provision of basic health care. The authors argue that if guidelines are adapted to local resources and needs, and employ a 'cascade' approach they can work.

    • M Fried
    • EMM Quigley
    • R Horton
    Reviews
    Nature Clinical Practice Gastroenterology & Hepatology
    Volume: 5, P: 2-3

  • Evidence-based guidelines from wealthy countries define optimum goals for resource-constrained countries. This Viewpoint article discusses how health-care policy in developing countries can only be influenced through local involvement in the construction and implementation of guidelines. The authors also discuss the potential yet controversial role of the biomedical industry in facilitating the development and dissemination of global guidelines.

    • M Fried
    • EMM Quigley
    • R Horton
    Reviews
    Nature Clinical Practice Gastroenterology & Hepatology
    Volume: 5, P: 120-121

  • Knee arthroscopy, the most common orthopaedic procedure, is used to treat middle-aged or elderly patients with knee pain, with over two million patients undergoing this surgery every year worldwide. A new clinical practice guideline advises against the use of arthroscopy in these patients, contradicting the common use of this procedure in clinical practice.

    • Teppo L. N. Järvinen
    • Gordon H. Guyatt
    News & Views
    Nature Reviews Rheumatology
    Volume: 13, P: 515-516

  • With a growing number of studies applying generative artificial intelligence (GAI) models for health purposes, reporting standards are being developed to guide authors in this space. We describe the currently available reporting guidelines that apply to GAI models and provide an overview of upcoming reporting standards. Investigators must remain up-to-date with the most applicable tools to guide the comprehensive reporting of their research as we integrate GAI in healthcare.

    • Bright Huo
    • Gary S. Collins
    • Gordon Guyatt
    Comments & OpinionOpen Access
    npj Digital Medicine
    Volume: 8, P: 1-4