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Perioperative durvalumab plus chemotherapy plus new agents for resectable non-small-cell lung cancer: the platform phase 2 NeoCOAST-2 trial

As presented at the 2025 ASCO Annual Meeting: in a randomized platform phase II trial, high rates of pathologic complete response were seen for neoadjuvant durvalumab plus chemotherapy when combined with new agents, most notably a TROP2-targeting antibody–drug conjugate, in patients with resectable non-small-cell lung cancer.

Tina Cascone
Laura Bonanno
Patrick M. Forde
ResearchOpen Access31 May 2025
Nature Medicine

Volume: 31, P: 2788-2796
The ATR inhibitor ceralasertib potentiates cancer checkpoint immunotherapy by regulating the tumor microenvironment

The ATR inhibitor ceralasertib has shown clinical activity in combination with immune-checkpoint inhibitors in several cancer types. Here the authors report the anti-tumor activity and the immunomodulatory changes, dependent on up-regulation of type I interferon pathway, following intermittent ATR inhibition in preclinical cancer models.

Elizabeth L. Hardaker
Emilio Sanseviero
Simon T. Barry
ResearchOpen Access24 Feb 2024
Nature Communications

Volume: 15, P: 1-20
A cellular census of human lungs identifies novel cell states in health and in asthma

Single-cell transcriptomics reveals immune and stromal compartment remodeling, including the enrichment of unique populations of epithelial cells and CD4⁺ T cells, in asthmatic lungs

Felipe A. Vieira Braga
Gozde Kar
Sarah A. Teichmann
Research17 Jun 2019
Nature Medicine

Volume: 25, P: 1153-1163
Ferroptosis of tumour neutrophils causes immune suppression in cancer

Pathologically activated neutrophils, termed myeloid-derived suppressor cells, in the tumour microenvironment spontaneously undergo ferroptosis, which negatively regulates anti-tumour immunity through the release of oxygenated lipids, therefore limiting the activity of human and mouse T cells.

Rina Kim
Ayumi Hashimoto
Dmitry I. Gabrilovich
Research16 Nov 2022
Nature

Volume: 612, P: 338-346
Tumors induce de novo steroid biosynthesis in T cells to evade immunity

Multiple mechanisms of immune evasion exploited by cancer cells have been described. Here, the authors show that genetic inactivation or pharmacological inhibition of tumor-induced Th2-mediated de novo steroidogenesis are sufficient to restore an efficient anti-tumor immune response and restrict tumor growth.

Bidesh Mahata
Jhuma Pramanik
Sarah A. Teichmann
ResearchOpen Access17 Jul 2020
Nature Communications

Volume: 11, P: 1-15
Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors

The liver parenchyma consists of several cell types, but the origin of this tissue in humans is unclear. Here, the authors perform single cell RNA sequencing of human fetal and adult liver to identify a hepatobiliary hybrid progenitor population of cells, which have a similar gene signature to mouse oval cells.

Joe M. Segal
Deniz Kent
S. Tamir Rashid
ResearchOpen Access26 Jul 2019
Nature Communications

Volume: 10, P: 1-14
Flipping between Polycomb repressed and active transcriptional states introduces noise in gene expression

Polycomb repressive complexes modify histones but it is unclear how changes in chromatin states alter kinetics of transcription. Here, the authors use single-cell RNAseq and ChIPseq to find that actively transcribed genes with Polycomb marks have greater cell-to-cell variation in expression.

Gozde Kar
Jong Kyoung Kim
Sarah A. Teichmann
ResearchOpen Access26 Jun 2017
Nature Communications

Volume: 8, P: 1-14
Wounding induces dedifferentiation of epidermal Gata6⁺ cells and acquisition of stem cell properties

Donati et al. show that following skin wounding a differentiated Gata6⁺ cell population resident in the sebaceous duct migrates to the interfollicular epidermis and reattaches to the basal membrane, dedifferentiating into stem cells.

Giacomo Donati
Emanuel Rognoni
Fiona M. Watt
Research15 May 2017
Nature Cell Biology

Volume: 19, P: 603-613
Single-cell RNA-sequencing resolves self-antigen expression during mTEC development

Ricardo J. Miragaia
Xiuwei Zhang
Tapio Lönnberg
ResearchOpen Access12 Jan 2018
Scientific Reports

Volume: 8, P: 1-13

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