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Showing 1–4 of 4 results
Advanced filters: Author: Grégory Effantin Clear advanced filters

  • Only praziquantel is available for treating schistosomiasis, a disease affecting >200 million people. Here, the authors identify compounds active against schistosome infections meeting the criteria for lead progression indicated by WHO with better activity against juvenile worms than praziquantel.

    • Valentina Z. Petukhova
    • Sammy Y. Aboagye
    • Pavel A. Petukhov
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-19

  • RNA-dependent RNA polymerases from segmented negative stranded RNA viruses catalyze genome replication and viral transcription. Here, the authors present the cryo-EM structure of full-length La Crosse virus polymerase and structurally characterize the pre-initiation and elongation states, which is of interest for the development of polymerase inhibitors.

    • Benoît Arragain
    • Grégory Effantin
    • Hélène Malet
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13

  • Host cell recognition is mediated by the phage tail tip proteins, which then triggers viral genome delivery via the phage tail. Here, the authors combine crystallography and cryoEM to structurally characterise the bacteriophage T5 tail tube structure before and after interaction with its host receptor.

    • Charles-Adrien Arnaud
    • Grégory Effantin
    • Cécile Breyton
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-9

  • The retromer is a complex of Vacuolar protein sorting proteins that mediate retrieval of lysosomal hydrolases from endosomes to the trans golgi network. The human retromer complex can be separated into two smaller complexes, a membrane targeting sorting nexin dimer and a heterotrimeric cargo recognition complex. New and previously solved structures, bioinformatics, interaction studies, molecular modelling and electron microscopy of the entire complex are combined to develop a structural model of the complex.

    • Aitor Hierro
    • Adriana L. Rojas
    • James H. Hurley
    Research
    Nature
    Volume: 449, P: 1063-1067