Nature Search

Human assembloid model of the ascending neural sensory pathway

A human ascending somatosensory assembloid model was developed, which integrates multiple organoids to simulate the spinothalamic pathway, demonstrating functional connectivity and responsiveness to stimuli and revealing insights into pain-related genetic mutations.

Ji-il Kim
Kent Imaizumi
Sergiu P. Pașca
ResearchOpen Access09 Apr 2025
Nature

Volume: 642, P: 143-153
A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin

Microtubule-targeting agents are used successfully as anticancer therapeutics. Here authors develop a fluorescence-anisotropy-based assay to identify and characterize ligands for the maytansine site of tubulin and provide crystal structures of identified ligands in complex with tubulin.

Grégory Menchon
Andrea E. Prota
Michel O. Steinmetz
ResearchOpen Access29 May 2018
Nature Communications

Volume: 9, P: 1-9
Neural circuit basis of placebo pain relief

Analgesia from the expectation of pain relief is mediated by rostral anterior cingulate cortex neurons that project to the pontine nucleus.

Chong Chen
Jesse K. Niehaus
Grégory Scherrer
ResearchOpen Access24 Jul 2024
Nature

Volume: 632, P: 1092-1100
A modulator-bound GPCR structure enables allosteric non-opioid analgesia

Structural studies of a positive allosteric modulator of the adenosine A₁ receptor demonstrate the mechanisms by which stabilization of the GPCR–G protein complex bound to its endogenous agonist yields analgesic efficacy in an animal model of neuropathic pain.

David F. Lee
Matan Geron
Grégory Scherrer
News & Views09 Nov 2021
Nature Structural & Molecular Biology

Volume: 28, P: 871-872
Structure-based discovery of opioid analgesics with reduced side effects

Computational docking to the the μ-opioid-receptor identifies PZM21, a novel selective biased agonist that generates substantial affective analgesia in mice without altering respiration or inducing drug reinforcement.

Aashish Manglik
Henry Lin
Brian K. Shoichet
Research17 Aug 2016
Nature

Volume: 537, P: 185-190
Impaired Hippocampus-Dependent and Facilitated Striatum-Dependent Behaviors in Mice Lacking the Delta Opioid Receptor

Julie Le Merrer
Xavier Rezai
Brigitte L Kieffer
Research04 Jan 2013
Neuropsychopharmacology

Volume: 38, P: 1050-1059
Loss of μ opioid receptor signaling in nociceptors, but not microglia, abrogates morphine tolerance without disrupting analgesia

μ opioid receptors (MORs) expressed on primary afferent nociceptor neurons are responsible for two maladaptive side-effects of chronic opioid use: opioid tolerance and opioid-induced hyperalgesia (pain). A combination therapy of opioid receptor agonism plus peripheral-restricted MOR antagonism abrogates these side-effects while preserving opioid analgesia in rodent models of peri-operative and chronic pain.

Gregory Corder
Vivianne L Tawfik
Grégory Scherrer
Research16 Jan 2017
Nature Medicine

Volume: 23, P: 164-173
Graph theory analysis reveals an assortative pain network vulnerable to attacks

Chong Chen
Adrien Tassou
Grégory Scherrer
ResearchOpen Access11 Dec 2023
Scientific Reports

Volume: 13, P: 1-14
Segmentation and quantification of subcellular structures in fluorescence microscopy images using Squassh

Aurélien Rizk
Grégory Paul
Ivo F Sbalzarini
Protocols13 Feb 2014
Nature Protocols

Volume: 9, P: 586-596

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