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Showing 1–3 of 3 results
Advanced filters: Author: Grégory Verdon Clear advanced filters

  • This study explores apelin receptor’s role in cardiovascular function, identifying residues critical for binding through genetic variants, AlphaFold2 modelling and base editing in cardiomyocytes. Co-crystallization with biased agonist CMF-019 shows a unique binding mode versus endogenous peptides.

    • Thomas L. Williams
    • Grégory Verdon
    • Anthony P. Davenport
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-19

  • This study has determined the X-ray crystal structures of GLUT5 from Rattus norvegicus in an open, outward-facing conformation and GLUT5 from Bos taurus in an open, inward-facing conformation; comparison of these structures with previously published structures of the related Escherichia coli d-xylose:H+ symporter XylE suggests that transport in GLUT5 is controlled by both a global ‘rocker-switch’-type motion and a local ‘gated-pore’-type transport mechanism.

    • Norimichi Nomura
    • Grégory Verdon
    • David Drew
    Research
    Nature
    Volume: 526, P: 397-401

  • Glutamate transporters couple the uptake of glutamate to the transport of cations. A new crystal structure of an archaeal trimeric glutamate transporter homolog, GltPh, captured in an intermediate conformation between the outward and inward facing states, provides insights into the transport mechanism.

    • Grégory Verdon
    • Olga Boudker
    Research
    Nature Structural & Molecular Biology
    Volume: 19, P: 355-357