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Showing 1–4 of 4 results
Advanced filters: Author: Grace Khuu Clear advanced filters

  • Autophagy is initiated by the Unc-51-like kinase protein kinase complex (ULK1C) and class III phosphatidylinositol 3-OH kinase complex I (PI3KC3-C1). Here, the authors reveal the structure of the 2:1:1 core of ULK1C and its complex with PI3KC3-C1. ULK1C transitions to a 2:2:2 complex in the presence of PI3KC3-C1, suggesting a mechanism for autophagy induction.

    • Minghao Chen
    • Thanh N. Nguyen
    • James H. Hurley
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 32, P: 1596-1605

  • Mitophagy is an important quality control pathway. Here, the authors identify the mechanisms enabling the TBK1 adaptors NAP1 and SINTBAD to prevent hyperactivation of PINK1/Parkin mitophagy while promoting the pathway once set in motion.

    • Elias Adriaenssens
    • Thanh Ngoc Nguyen
    • Sascha Martens
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 31, P: 1717-1731

  • Influenza B viruses are linked to significant morbidity and mortality, and yet their immunobiology is comparatively poorly understood. Here Menon et al identify influenza B virus-specific CD8+ T cell epitopes and characterise these in adults, children and the elderly.

    • Tejas Menon
    • Patricia T. Illing
    • Katherine Kedzierska
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-21