Osteopontin is a critical mediator of post-ischemic neovascularization. Humans express three primary OPN isoforms: OPNa, OPNb, and OPNc. This study demonstrates that OPN isoforms differentially promote functional post-ischemic arteriogenesis by promoting increased macrophage migration and macrophage accumulation and survival. Future studies will determine the molecular mechanisms underlying these divergent effects.
- Grace Sanghee Lee
- Hector F. Salazar
- Alicia N. Lyle