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Molecular basis for human respiratory syncytial virus transcriptional regulator NS1 interactions with MED25

This study provides the structural and biochemical characterization of the RSV NS1/MED25 ACID complex, revealing how RSV exploits fuzzy interfaces between coactivators and transcription factors, including ATF3, to modulate host gene transcription.

Parismita Kalita
Oam Khatavkar
Daisy W. Leung
ResearchOpen Access25 Mar 2025
Nature Communications

Volume: 16, P: 1-14

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Molecular basis for human respiratory syncytial virus transcriptional regulator NS1 interactions with MED25

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