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Showing 1–2 of 2 results
Advanced filters: Author: Gracie J. Mead Clear advanced filters

  • Losing sensitivity to IFNγ may contribute to tumor immune escape, but containment of IFNγ-insensitive tumors is also reported. Here the authors show, by analyzing immune landscape differences between WT and IFNγ receptor-deficient mouse B16-F10 melanoma tumors, that local IFNγ induces complex cellular crosstalk to promote anti-tumor immunity in the latter scenario.

    • Vivian W. C. Lau
    • Gracie J. Mead
    • Audrey Gérard
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19

  • Interactions between Semaphorin-3A (SEMA3A) and Neuropilin-1 (NRP1) and Plexin-A1 and Plexin-A4 have been shown to affect T cell development. Here the authors investigate how these interactions affect CD8+ T cells in tumour immunity, showing that NRP-1, Plexin-A1 and Plexin-A4 are upregulated on T cells allowing tumour derived SEMA3A to inhibit CD8+ T cell migration and function.

    • Mike B. Barnkob
    • Yale S. Michaels
    • Vincenzo Cerundolo
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18