The authors of this Review consider how a reduced prevalence of organisms that have been part of human microecology for millennia (including saprophytic mycobacteria, bifidobacteria, lactobacilli, and helminths) and cause little, if any, harm to the host, might explain the increased prevalence of immune-mediated disorders in westernized countries.
- Francisco Guarner
- Raphaëlle Bourdet-Sicard
- Graham AW Rook
