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  • Little is known about the developmental causes of aortic root defects. Here the authors show that the inactivation of Sox17 in aortic root endothelium results in aortic root defects affecting aortic valve and coronary ostium.

    • Pengfei Lu
    • Ping Wang
    • Bin Zhou
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17