GPR88 is an orphan G protein–coupled receptor expressed in striatal medium spiny neurons (MSNs). The authors show that deletion of Gpr88 in mice leads to hyperactivity, poor motor coordination and impaired cue-based learning. MSNs lacking GPR88 show increased excitation and reduced inhibition in vitro, and enhanced firing rates in vivo.
- Albert Quintana
- Elisenda Sanz
- Richard D Palmiter
