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Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways

Qing Xu
Jon Briggs
Hua Yu
Research20 Jun 2005
Oncogene

Volume: 24, P: 5552-5560
HIF-1α, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas

Michael J Gray
Jing Zhang
Gary E Gallick
Research21 Feb 2005
Oncogene

Volume: 24, P: 3110-3120
DETECTION OF A NOVEL DNA POLYMORPHISM IN THE β-GLOBIN CLUSTER AND EVIDENCE FOR SITE-SPECIFIC RECOMBINATION

Gregg L Semenza
Padmini Malladi
Saul Surrey
Research01 Apr 1984
Pediatric Research

Volume: 18, P: 225
THE SILENT CARRIER ALLELE: β-THALASSEMIA WITHOUT A MUTATION IN THE β-GLOBIN GENE REGION

Gregg L Semenza
Kathleen Delgrosso
Mortimer Ponca
Research01 Apr 1984
Pediatric Research

Volume: 18, P: 248
HIF-1 Interacts with TRIM28 and DNA-PK to release paused RNA polymerase II and activate target gene transcription in response to hypoxia

Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that modulates target gene expression in response to changes in oxygen availability. Here the authors show that HIF-1 forms a complex with TRIM28 and DNA-dependent protein kinase (DNA-PK) that phosphorylates TRIM28. This leads to CDK9 recruitment, which stimulates RNA polymerase II (RNAPII) pause release and transcriptional elongation.

Yongkang Yang
Haiquan Lu
Gregg L. Semenza
ResearchOpen Access14 Jan 2022
Nature Communications

Volume: 13, P: 1-16
A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension

Pulmonary hypertension is characterized by a metabolic switch similar to the Warburg effect in cancer. Here Dabral et al. describe a RASSF1a-HIF-1α feedforward loop driving the Warburg effect both in a mouse model of hypoxia-induced pulmonary hypertension and a subset of human cancer cells.

Swati Dabral
Christian Muecke
Soni S. Pullamsetti
ResearchOpen Access13 May 2019
Nature Communications

Volume: 10, P: 1-18
Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia

Sonny O. Ang
Hua Chen
Josef T. Prchal
Research04 Nov 2002
Nature Genetics

Volume: 32, P: 614-621
A genetic mechanism for Tibetan high-altitude adaptation

Josef Prchal and colleagues identify a mutation in EGLN1 associated with adaptation to high altitude in Tibetan individuals. Their functional studies suggest a mechanism acting to reduce the erythropoietic response to hypoxia.

Felipe R Lorenzo
Chad Huff
Josef T Prchal
Research01 Sept 2014
Nature Genetics

Volume: 46, P: 951-956
Hypoxia and the extracellular matrix: drivers of tumour metastasis

Emerging data indicate that hypoxia and the extracellular matrix (ECM) together might have a crucial role in metastasis. In this Opinion article the authors suggest a model in which multiple microenvironmental signals might converge to synergistically influence metastatic outcome.

Daniele M. Gilkes
Gregg L. Semenza
Denis Wirtz
Reviews15 May 2014
Nature Reviews Cancer

Volume: 14, P: 430-439
Hypoxia pathway linked to kidney failure

A mechanism that may underlie a form of human kidney failure has been delineated in knockout mice. Activation of the oxygen-regulated transcription factor Hif1 and its target gene Cxcr4 leads to increased cell proliferation that interferes with the function of the glomerulus (pages 1071–1077).

Gregg L Semenza
News & Views01 Sept 2006
Nature Medicine

Volume: 12, P: 996-997
Targeting HIF-1 for cancer therapy

Gregg L. Semenza
Reviews01 Dec 2003
Nature Reviews Cancer

Volume: 3, P: 721-732
Lack of Evidence for Vasoactive and Inflammatory Mediators in the Promotion of Macular Edema Associated with Epiretinal Membranes

Brooks P. Applewhite
Savalan Babapoor-Farrokhran
Akrit Sodhi
ResearchOpen Access06 Sept 2017
Scientific Reports

Volume: 7, P: 1-10
A physical sciences network characterization of non-tumorigenic and metastatic cells

David B. Agus
Jenolyn F. Alexander
Pei-Hsun Wu
ResearchOpen Access26 Apr 2013
Scientific Reports

Volume: 3, P: 1-12
Glutaminase 1 expression in colorectal cancer cells is induced by hypoxia and required for tumor growth, invasion, and metastatic colonization

Lisha Xiang
Jun Mou
Ganfeng Xie
ResearchOpen Access17 Jan 2019
Cell Death & Disease

Volume: 10, P: 1-15
Hypoxia-Inducible Factor 1: Control of Oxygen Homeostasis in Health and Disease

Gregg L Semenza
Reviews01 May 2001
Pediatric Research

Volume: 49, P: 614-617

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