The degenerative joint disease osteoarthritis is known to involve the activation of the protease ADAMTS-5. Now, Frank Echtermeyer and his colleagues have shown that the transmembrane proteoglycan syndecan-4 is responsible for this activation. They also show that genetic deletion of syndecan-4, or inhibition with a blocking antibody, reduces disease progression in a mouse model.
- Frank Echtermeyer
- Jessica Bertrand
- Thomas Pap
