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Showing 1–5 of 5 results
Advanced filters: Author: Gregory I Vladimer Clear advanced filters

  • Epigenome profiling in combination with imaging-based chemosensitivity and integrative bioinformatic analysis establishes a method for detecting therapy-induced vulnerabilities, as shown here for ibrutinib-treated chronic lymphocytic leukemia.

    • Christian Schmidl
    • Gregory I. Vladimer
    • Christoph Bock
    Research
    Nature Chemical Biology
    Volume: 15, P: 232-240

  • A high-content screening platform that measures the immunological potential of small-molecule and biologic drugs by computationally determining changes in the physical interactions among peripheral mononuclear leukocytes revealed known immunomodulators and also approved drugs as regulators of unexpected targets, including MST1R.

    • Gregory I Vladimer
    • Berend Snijder
    • Giulio Superti-Furga
    Research
    Nature Chemical Biology
    Volume: 13, P: 681-690

  • Primary immunodeficiency disorders can be used to identify key immune functions. Here, the authors identify a biallelic mutation in the gene encoding NF-κB-inducing kinase in a family suffering a range of infections, and show that it causes defects in NK and T-cell function and has broad effects on B-cell function.

    • Katharina L. Willmann
    • Stefanie Klaver
    • Kaan Boztuğ
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-13

  • Fibroblast-like synoviocytes (FLS) are major contributors to joint inflammation in rheumatoid arthritis (RA). Here, the authors identified a previously unknown signaling circuit that contributes to tumor necrosis factor (TNF)-induced activation of FLS. The authors show that FOXO3 and its modulator PIK3IP1 are crucial for the TNF-driven interferon (IFN) response in RA-FLS.

    • Bernhard Brandstetter
    • Karolina Dalwigk
    • Thomas Karonitsch
    Research
    Laboratory Investigation
    Volume: 99, P: 648-658