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Showing 1–3 of 3 results
Advanced filters: Author: Gregory J. Tesz Clear advanced filters

  • Liver and adipose tissue are shown to use different metabolic routes to generate NADPH for de novo lipogenesis, with the liver relying on a unique cytosolic serine catabolic pathway involving the enzyme SHMT1.

    • Zhaoyue Zhang
    • Tara TeSlaa
    • Joshua D. Rabinowitz
    Research
    Nature Metabolism
    Volume: 3, P: 1608-1620

  • RNA interference (RNAi) is a robust gene silencing mechanism that degrades mRNAs complementary to the antisense strands of double-stranded, short interfering RNAs. This Review describes the current status of research and clinical trials on RNAi-based therapeutics and addresses novel potential targets for the treatment of metabolic disease.

    • Michael P. Czech
    • Myriam Aouadi
    • Gregory J. Tesz
    Reviews
    Nature Reviews Endocrinology
    Volume: 7, P: 473-484