Altered expression of specific Ca2+ channels and pumps are characterizing features of some cancers. The ability of Ca2+ to regulate both cell death and proliferation, combined with the potential for pharmacological modulation, offers the opportunity for a set of new drug targets in cancer. Which Ca2+channels and pumps should be targeted and what strategy should be used?
- Gregory R. Monteith
- Damara McAndrew
- Sarah J. Roberts-Thomson