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Showing 1–6 of 6 results
Advanced filters: Author: Grigory Genikhovich Clear advanced filters

  • Lebedeva et al. show that unlike Bilateria, the embryo of the cnidarian Nematostella specifies its endomesoderm in the β-catenin-negative domain. In contrast, subsequent β-catenin-dependent axial patterning acts similarly in Cnidaria and Bilateria.

    • Tatiana Lebedeva
    • Johan Boström
    • Grigory Genikhovich
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-10

  • In vertebrate embryos, Wnt/β-catenin signaling induces an organizer area guiding the formation of body axes and inducing extra axes upon transplantation. Here, Kraus et al. show that Wnt ligands also induce an organizer in a sea anemone, indicating that the organizer dates back over 600 million years.

    • Yulia Kraus
    • Andy Aman
    • Grigory Genikhovich
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-9

  • The authors show in Nematostella that the more orally expressed β-catenin targets repress the more aborally expressed β-catenin targets, thus patterning the oral-aboral axis. This likely represents the common mechanism of β-catenin-dependent axial patterning shared by Cnidaria and Bilateria.

    • Tatiana Lebedeva
    • Andrew J. Aman
    • Grigory Genikhovich
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • Recent work suggested that diploblast embryos (Cnidaria) may have germ layers that are similar to those seen in bilaterians, but how these are specified remained unclear. Here, they use scRNA-seq and functional analyses to identify the signaling involved in germ layer segregation in Cnidaria.

    • Emmanuel Haillot
    • Tatiana Lebedeva
    • Ulrich Technau
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • Slowly evolving cnidarians are useful models to study genome architecture. This study shows that sea anemones have a high degree of chromosomal macrosynteny, but poor microsynteny conservation. This is correlated with a small genome size and short distances of cis-regulatory elements to genes.

    • Bob Zimmermann
    • Juan D. Montenegro
    • Ulrich Technau
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16

  • Brachyury is an early mesoderm determinant and neural repressor in vertebrates. Comparative Brachyury target screens between a sea anemone and a sea urchin reveal an ancestral gene regulatory feedback loop involved in axial patterning, with conserved endodermal and neuronal, but not mesodermal, targets.

    • Michaela Schwaiger
    • Carmen Andrikou
    • Ulrich Technau
    Research
    Nature Ecology & Evolution
    Volume: 6, P: 1921-1939