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Showing 1–11 of 11 results
Advanced filters: Author: Grigory Maksaev Clear advanced filters

  • Trypanosoma cruzi, the protozoan parasite causing Chagas disease, encodes a miniature mechanosensitive channel critical for development and infectivity. Here, the authors reveal a direct lipid-mediated mechanical gating transition upon channel activation.

    • Jingying Zhang
    • Aashish Bhatt
    • Peng Yuan
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11

  • Here, authors introduced negative charges in the transmembrane helices in Kir2.2 channels generating pH-dependent sub-conductances. Molecular dynamics simulations show how protonation results in step-wise alterations of ion pooling and hence conductance, appearing as gated substates.

    • Grigory Maksaev
    • Michael Bründl-Jirout
    • Colin G. Nichols
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-11

  • Mechanosensitive channels transduce physical force into electrochemical signaling in processes such as hearing, touch, proprioception, osmoregulation, and morphogenesis. Here, authors use cryo-electron microscopy to provide structural insights into the mechanical gating mechanism.

    • Zengqin Deng
    • Grigory Maksaev
    • Peng Yuan
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-9

  • Cryo-EM structures of TRPV3 in nanodiscs reveal lipids bound to the channel and unprecedented conformations of the selectivity filter and of the pore-lining helix S6, underscoring the importance of lipids for the channel structure.

    • Zengqin Deng
    • Grigory Maksaev
    • Peng Yuan
    Research
    Nature Structural & Molecular Biology
    Volume: 27, P: 635-644

  • The Arabidopsis mechanosensitive channel MSL10 plays a crucial role in hypo-osmotic shock adaptation and programmed cell death induction. Here, the authors reveal the structural mechanism underlying MSL10 channel gating.

    • Jingying Zhang
    • Grigory Maksaev
    • Peng Yuan
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-9

  • Single-molecule FRET shows that a loop, which forms the selectivity filter in the bacterial inwardly rectifying K+ channel KirBac1.1, transitions between constrained and dilated conformations depending on ion occupancy of the filter.

    • Shizhen Wang
    • Sun-Joo Lee
    • Colin G. Nichols
    Research
    Nature Chemical Biology
    Volume: 15, P: 377-383

  • Cryo-EM structures of plasma membrane ATP release channel pannexin 1 reveal heptameric architecture, wide pore and a constriction potentially restricting the size of permeable substrates. Combined with functional assays, they offer insights into channel gating.

    • Zengqin Deng
    • Zhihui He
    • Peng Yuan
    Research
    Nature Structural & Molecular Biology
    Volume: 27, P: 373-381

  • Identification of TRPV3 channel residues interacting with intracellular spermine and high resolution structure of a non-conducting TRPV3 in the presence of NASPM suggest a unifying molecular model to explain spermine block of TRPV1-4 channels.

    • Jingying Zhang
    • Peng Yuan
    • Grigory Maksaev
    ResearchOpen Access
    Communications Biology
    Volume: 8, P: 1-12