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Showing 1–20 of 20 results
Advanced filters: Author: Guadalupe Sabio Clear advanced filters

  • How adipose mitochondria activity is fine-tuned in response to obesity is an active area of study. Here, the authors show that mitochondrial protein MCJ can block thermogenesis and that silencing this gene can correct obesity-related comorbidities.

    • Beatriz Cicuéndez
    • Alfonso Mora
    • Guadalupe Sabio
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • Drug resistance remains a major challenge in cancer treatment. Here, the authors identify Connexin43 as target that enhances BRAF/MEKi efficacy by interfering with DNA repair pathways, overcoming drug resistance. They develop an mRNA therapy that improves efficacy and sensitizes resistant cells.

    • Adrián Varela-Vázquez
    • Amanda Guitián-Caamaño
    • María D. Mayán
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20

  • Romero-Becerra et al. report that stress kinases p38γ and p38δ are activated in ventricles of old mice and in arrhythmogenic conditions, and they demonstrate that p38γ/δ -driven phosphorylation of RyR2 and SAP97 is a trigger for ventricular fibrillation.

    • Rafael Romero-Becerra
    • Francisco M. Cruz
    • Guadalupe Sabio
    Research
    Nature Cardiovascular Research
    Volume: 2, P: 1204-1220

  • Adipose tissue accommodates large volume changes upon expansion, but the molecular mechanisms involved are not fully understood. Here, Aboy et al. describe CAV1 Y14 phosphorylation as required for appropriate adipocyte caveolae flattening and homeostasis.

    • María C. M. Aboy-Pardal
    • Marta C. Guadamillas
    • Miguel A. Del Pozo
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-27

  • G49, a dual glucagon/glucagon-like peptide-1 receptor agonist, triggers an inter-organ crosstalk between adipose tissue, pancreas and liver, leading to brown fat activation with the final outcomes of increased energy expenditure and body weight loss.

    • M. Pilar Valdecantos
    • Laura Ruiz
    • Ángela M. Valverde
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-29

  • The liver is segregated into spatially organized areas that serve distinct functions, though how these zones are patterned remains unclear. Here they show that mTORC1 controls spatial segregation of liver metabolic functions via modulation of Wnt signaling, and find that impaired zonation is also observed in pigs given total parenteral nutrition.

    • Ana Belén Plata-Gómez
    • Lucía de Prado-Rivas
    • Alejo Efeyan
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-19

  • Extended exposure to breastfeeding in rodent pups protects them from diet-induced obesity in adulthood by increasing thermogenesis and energy expenditure. This is mediated by liver-derived FGF21 signalling to the lateral hypothalamic area.

    • Veronica Pena-Leon
    • Cintia Folgueira
    • Luisa M. Seoane
    ResearchOpen Access
    Nature Metabolism
    Volume: 4, P: 901-917

  • p53 regulates signalling pathways involved in metabolic homeostasis. Here the authors show that O-GlcNAcylation of p53 in the liver plays a key role in the physiological regulation of glucose homeostasis, potentially via controlling the expression of the gluconeogenic enzyme phosphoenolpyruvate carboxykinase.

    • Maria J. Gonzalez-Rellan
    • Marcos F. Fondevila
    • Ruben Nogueiras
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-21

  • High methionine and S-adenosylmethionine serum levels are related with obesity. Here the authors show that knockdown of methionine adenosyltransferase by using antisense oligonucleotides provides beneficial effects in obesity and comorbidities.

    • Diego Sáenz de Urturi
    • Xabier Buqué
    • Patricia Aspichueta
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-19

  • The mechanistic target of rapamycin complex 1 (mTORC1) integrates nutrient and hormonal signals to control metabolism. Here the authors investigate the effects of constitutive nutrient signaling through genetic activation of RagA in adult mice and show that constitutive nutrient signaling regulates the response to feeding-fasting cycles and does not drive liver cancer.

    • Celia de la Calle Arregui
    • Ana Belén Plata-Gómez
    • Alejo Efeyan
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-20

  • Obesity activates stress-activated protein kinases (SAPKs), such as the p38 and JNK stress kinases, in several tissues, including adipose, liver, skeletal muscle, immune organs and the central nervous system. This Review discusses the role of SAPKs in metabolic control and highlights important discoveries in the field.

    • Ivana Nikolic
    • Magdalena Leiva
    • Guadalupe Sabio
    Reviews
    Nature Reviews Endocrinology
    Volume: 16, P: 697-716

  • p53 regulates lipid metabolism and fatty acid oxidation, and its inactivation promotes diet-induced liver steatosis. Here Porteiroet al. show that p53 deficiency leads to compensatory p63 upregulation, which, in turn, triggers endoplasmic reticulum stress through IKKβ activation, fatty acid synthesis and lipid accumulation.

    • Begoña Porteiro
    • Marcos F. Fondevila
    • Ruben Nogueiras
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-19

  • mTOR signalling pathway is a critical regulator of cardiac hypertrophy. Here the authors show that two kinases, p38γ and p38δ, control heart growth by promoting mTOR activity via phosphorylation and consequent proteasome degradation of mTOR inhibitor DEPTOR, extending our knowledge of cardiac hypertrophy regulation.

    • Bárbara González-Terán
    • Juan Antonio López
    • Guadalupe Sabio
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-16

  • Emerging studies suggest that p53 is an important regulator of energy metabolism, yet there is little known about the metabolic function of this tumor suppressor in the hypothalamus. Here, authors illustrate that p53, specifically in AgRP neurons, is required for adaptation to diet-induced obesity.

    • Mar Quiñones
    • Omar Al-Massadi
    • Ruben Nogueiras
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-16

  • Brown and beige adipose tissues dissipate heat via uncoupling protein 1 (UCP1). Here the authors show that the stress activated kinase MKK6 acts as a repressor of UCP1 expression, suggesting that its inhibition promotes adipose tissue browning and increases organismal energy expenditure.

    • Nuria Matesanz
    • Edgar Bernardo
    • Guadalupe Sabio
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-14

  • The stress-activated kinase p38γ has a role in regulating entry into the cell cycle; in the liver, it can induce cellular proliferation during regeneration and promote the development of hepatocellular carcinoma.

    • Antonia Tomás-Loba
    • Elisa Manieri
    • Guadalupe Sabio
    Research
    Nature
    Volume: 568, P: 557-560