The mouse retina includes cone photoreceptors optimized for short (S) and medium (M) wavelengths; the difference lies in the expression of S and M opsin. Onishi and colleagues find that, in M cones, thyroid hormone–responsive transcription factors induce expression of the SUMO ligase Pias3, whose activity is necessary for repression of S opsin and expression of M opsin.
- Akishi Onishi
- Guang-Hua Peng
- Seth Blackshaw
