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4-alkyl-L-(Dehydro)proline biosynthesis in actinobacteria involves N-terminal nucleophile-hydrolase activity of γ-glutamyltranspeptidase homolog for C-C bond cleavage

γ-Glutamyltranspeptidases in gram-positive bacteria are not involved in glutathione metabolism, as their counterparts in eukaryotes and gram-negative bacteria. Here, the authors show that in Actinobacteria they catalyse the unusual cleavage of a C–C bond for the biosynthesis of non-proteinogenic amino acids.

Guannan Zhong
Qunfei Zhao
Wen Liu
ResearchOpen Access14 Jul 2017
Nature Communications

Volume: 8, P: 1-10
Rational construction of genome-reduced Burkholderiales chassis facilitates efficient heterologous production of natural products from proteobacteria

An efficient chassis for heterologous expression of biosynthetic gene clusters (BGCs) from Gram-negative bacteria is still unavailable. Here, the authors report rational construction of genome-reduced Burkholderials chassis to facilitate production of a class of new compounds by expressing BGC from Chitinimonas koreensis.

Jiaqi Liu
Haibo Zhou
Xiaoying Bian
ResearchOpen Access23 Jul 2021
Nature Communications

Volume: 12, P: 1-16
A randomized non-inferiority trial of therapeutic strategy with immunosuppressants versus biologics for Vogt-Koyanagi-Harada disease

Different classes of biologic therapeutics have been assessed in the context of Vogt-Koyanagi-Harada disease. Here the authors compared cyclosporine immunosuppression or adalimumab in a randomised clinical trial for the treatment of patients with Vogt-Koyanagi-Harada disease and found non-inferiority upon treatment with cyclosporine.

Zhenyu Zhong
Lingyu Dai
Peizeng Yang
ResearchOpen Access24 Jun 2023
Nature Communications

Volume: 14, P: 1-10
Long noncoding RNA NRON contributes to HIV-1 latency by specifically inducing tat protein degradation

Long noncoding RNAs have a wide range of physiological functions, though their role in viral infection and latency is poorly understood. Here the authors show a lncRNA NRON can induce degradation of HIV-1 protein Tat, potentially contributing to latent infection.

Jun Li
Cancan Chen
Hui Zhang
ResearchOpen Access13 Jun 2016
Nature Communications

Volume: 7, P: 1-10
Reply to ‘C–C bond cleavage in biosynthesis of 4-alkyl-l-proline precursors of lincomycin and anthramycin cannot precede C-methylation’

Guannan Zhong
Hua Chen
Wen Liu
CorrespondenceOpen Access09 Aug 2018
Nature Communications

Volume: 9, P: 1-3
Develop an efficient and specific AAV-based labeling system for Muller glia in mice

Yanxia Gao
Kailun Fang
Hui Yang
ResearchOpen Access27 Dec 2022
Scientific Reports

Volume: 12, P: 1-9

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4-alkyl-L-(Dehydro)proline biosynthesis in actinobacteria involves N-terminal nucleophile-hydrolase activity of γ-glutamyltranspeptidase homolog for C-C bond cleavage

Rational construction of genome-reduced Burkholderiales chassis facilitates efficient heterologous production of natural products from proteobacteria

A randomized non-inferiority trial of therapeutic strategy with immunosuppressants versus biologics for Vogt-Koyanagi-Harada disease

Long noncoding RNA NRON contributes to HIV-1 latency by specifically inducing tat protein degradation

Reply to ‘C–C bond cleavage in biosynthesis of 4-alkyl-l-proline precursors of lincomycin and anthramycin cannot precede C-methylation’

Develop an efficient and specific AAV-based labeling system for Muller glia in mice

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