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Showing 1–3 of 3 results
Advanced filters: Author: Guido Polles Clear advanced filters

  • Self-assembling of complex molecular structures with a target topology is of importance to design and synthesize functional materials. Here, Polles et al. demonstrate the spontaneous formation of closed knotted structures from simple helical building blocks with sticky ends in simulations.

    • Guido Polles
    • Davide Marenduzzo
    • Cristian Micheletti
    Research
    Nature Communications
    Volume: 6, P: 1-8

  • Here, using population-based modeling on ensemble Hi-C data, the authors provide an expansive overview of how the genic chromatin microenvironment influences its potential involvement in different functions, such as transcription, DNA replication, and chromatin compartmentalization. Their results unveil a key role of nuclear speckles in genome organization.

    • Asli Yildirim
    • Nan Hua
    • Frank Alber
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 30, P: 1193-1206