Nature Search

A benchmark of expert-level academic questions to assess AI capabilities

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Long Phan
Alice Gatti
Davide Scaramuzza
ResearchOpen Access28 Jan 2026
Nature

Volume: 649, P: 1139-1146
Functional analysis of single enzymes combining programmable molecular circuits with droplet-based microfluidics

Integrating droplet-based microfluidics with a modular DNA circuit, here the authors report on monitoring the amplification reaction from single enzyme molecules in real time, revealing the distribution of activity among the catalyst population and alternative inactivation pathways under various stresses.

Guillaume Gines
Rocίo Espada
Yannick Rondelez
Research26 Feb 2024
Nature Nanotechnology

Volume: 19, P: 800-809
Spatiotemporal control of DNA-based chemical reaction network via electrochemical activation in microfluidics

Ievgen Kurylo
Guillaume Gines
Alexis Vlandas
ResearchOpen Access23 Apr 2018
Scientific Reports

Volume: 8, P: 1-7
Synthesis and materialization of a reaction–diffusion French flag pattern

A DNA-based reaction network has now been developed that creates a French flag pattern with immobile and sharp borders from a shallow initial concentration gradient. The output pattern can be used to control the macroscopic organization of DNA-decorated particles thereby inducing a French flag pattern of colloidal aggregation.

Anton S. Zadorin
Yannick Rondelez
André Estevez-Torres
Research01 May 2017
Nature Chemistry

Volume: 9, P: 990-996
Boosting functionality of synthetic DNA circuits with tailored deactivation

Nonlinearity in synthetic molecular circuits is usually achieved by manipulation of network topology or of production kinetics. Here, the authors achieve bistability and other nonlinear behaviours by manipulating the individual degradation rate laws of circuit components using saturable pathways.

Kevin Montagne
Guillaume Gines
Yannick Rondelez
ResearchOpen Access15 Nov 2016
Nature Communications

Volume: 7, P: 1-12

Quick links

Search

Filter By:

A benchmark of expert-level academic questions to assess AI capabilities

Functional analysis of single enzymes combining programmable molecular circuits with droplet-based microfluidics

Spatiotemporal control of DNA-based chemical reaction network via electrochemical activation in microfluidics

Synthesis and materialization of a reaction–diffusion French flag pattern

Boosting functionality of synthetic DNA circuits with tailored deactivation

Search

Quick links