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Showing 1–7 of 7 results
Advanced filters: Author: Guillaume Morcrette Clear advanced filters

  • It remains unclear why some paediatric tumours appear to have such a low mutation burden. Here, the authors shed light on this paradox by analysing Wilms tumours using high resolution and high depth sequencing approaches, finding that - due to an unusual clonal architecture - standard methods significantly underestimate the mutation burden at the cellular level.

    • Henry Lee-Six
    • Taryn D. Treger
    • Sam Behjati
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-10

  • Reninomas are very rare kidney tumours of juxtaglomerular cells. Here, the authors analyse reninomas using whole-genome and transcriptome sequencing, and reveal the presence and functional effects of NOTCH1 rearrangements.

    • Taryn D. Treger
    • John E. G. Lawrence
    • Tanzina Chowdhury
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-10

  • Paediatric liver cancer is rare, and often associated with a predisposition syndrome. Here, the authors show that 11p15.5 mosaic alteration in the liver is a pre-neoplastic lesion associated with hepatoblastoma, and spatial transcriptomics together with single-nucleus RNAseq identify a an altered zonation in the liver of these patients.

    • Jill Pilet
    • Theo Z. Hirsch
    • Jessica Zucman-Rossi
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • Hepatoblastoma (HB) is the most frequent paediatric liver tumour with heterogeneous cellular phenotypes that influence clinical outcomes. Here, the authors integrate bulk, single-cell, and spatial multi-omics to characterise HB cells, and find that clonal evolution and epigenetic plasticity shape response to therapy.

    • Amélie Roehrig
    • Theo Z. Hirsch
    • Eric Letouzé
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • The eruption of the submarine Hunga volcano in January 2022 led to a 13% increase in global stratospheric water mass and a 5-fold increase in stratospheric aerosol load, according to satellite data complemented by ground-based observations and atmospheric transport modelling.

    • Sergey Khaykin
    • Aurelien Podglajen
    • François Ravetta
    ResearchOpen Access
    Communications Earth & Environment
    Volume: 3, P: 1-15

  • A study of the evolution of the SARS-CoV-2 virus in England between September 2020 and June 2021 finds that interventions capable of containing previous variants were insufficient to stop the more transmissible Alpha and Delta variants.

    • Harald S. Vöhringer
    • Theo Sanderson
    • Moritz Gerstung
    ResearchOpen Access
    Nature
    Volume: 600, P: 506-511