Proteasome structure is extensively conserved across a broad range of organisms, so it is not surprising that inhibitors of all chemical classes tested have blocked both eukaryotic and prokaryotic proteasomes. However, certain oxathiazol-2-one compounds are now shown to kill non-replicating Mycobacterium tuberculosis and act as selective inhibitors of the M. tuberculosis proteasome while largely sparing the human homologue.
- Gang Lin
- Dongyang Li
- Carl Nathan
