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Showing 1–8 of 8 results
Advanced filters: Author: Guillaume de Lartigue Clear advanced filters

  • GLP-1 is an incretin hormone and neuromodulator produced by gut enterocytes and CNS neurons. Brierley et al. find that GLP-1 from peripheral and central sources acts independently through distinct gut–brain circuits to suppress eating.

    • Daniel I. Brierley
    • Marie K. Holt
    • Stefan Trapp
    Research
    Nature Metabolism
    Volume: 3, P: 258-273

  • A study reveals a gut–brain sensory pathway through which the microbial component flagellin activates neuropod cells in the colon to signal the brain and reduce feeding in mice.

    • Winston W. Liu
    • Naama Reicher
    • Diego V. Bohórquez
    ResearchOpen Access
    Nature
    Volume: 645, P: 729-736

  • The ability to encode and recall information about food is critical for survival. We reveal that ventral hippocampus projections to the lateral hypothalamus encode meal-related memories, and that disruption of this circuit promotes excessive eating.

    • Léa Décarie-Spain
    • Cindy Gu
    • Scott E. Kanoski
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • Vagus nerve stimulation has shown promise in treating inflammatory bowel disease. A new study identifies a hepatic vagal branch pathway necessary to maintain colonic immune cell homeostasis in experimental colitis, challenging the dogma that an anti-inflammatory reflex requires an intact spleen and that α7-nicotinic receptor agonists are a panacea for inflammatory conditions.

    • Alan de Araujo
    • Guillaume de Lartigue
    News & Views
    Nature Reviews Gastroenterology & Hepatology
    Volume: 17, P: 651-652

  • Feeding-relevant vagal signaling occurs between the gastrointestinal tract and the brain, but it is unclear if this pathway influences cognitive processes. This study shows that endogenous gastrointestinal derived vagal sensory signaling promotes hippocampal-dependent memory function via a multi-order brainstem–septal pathway.

    • Andrea N. Suarez
    • Ted M. Hsu
    • Scott E. Kanoski
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-15