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Showing 1–5 of 5 results
Advanced filters: Author: Guillermo Abascal-Palacios Clear advanced filters

  • The eukaryotic RNA Polymerase III transcribes tRNAs, some ribosomal and spliceosomal RNAs. Here, the authors resolve a cryo-EM structure of human RNA Polymerase III in its apo form and complemented it with crystal structures and SAXS analysis of RPC5, revealing insights into the molecular mechanisms of Pol III transcription.

    • Ewan Phillip Ramsay
    • Guillermo Abascal-Palacios
    • Alessandro Vannini
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • Ty3 retrotransposon integrates with an exquisite specificity upstream of RNA Polymerase III-transcribed genes, such as transfer RNAs. Here the authors resolve a cryo-EM structure of an active Ty3 intasome in complex with a TFIIIB-bound tRNA promoter, shedding light into the molecular determinants of harmless retrotransposition.

    • Guillermo Abascal-Palacios
    • Laura Jochem
    • Alessandro Vannini
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • Detailed structures of yeast RNA polymerase III and its initiation complex shed light on how the transcription of essential non-coding RNAs begins and allow comparisons with other RNA polymerases.

    • Guillermo Abascal-Palacios
    • Ewan Phillip Ramsay
    • Alessandro Vannini
    Research
    Nature
    Volume: 553, P: 301-306

  • Transcription initiation by RNA polymerase III requires TFIIIB, a complex formed by Brf1/Brf2, TBP and Bdp1. Here, the authors describe the crystal structure of a Brf2-TBP-Bdp1 complex bound to a DNA promoter and characterize the role of Bdp1 in TFIIIB assembly and pre-initiation complex formation.

    • Jerome Gouge
    • Nicolas Guthertz
    • Alessandro Vannini
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-11