Degradation of chondroitin sulphate proteoglycans by chondroitinase ABC (ChABC) in the adult or injured rodent nervous system is known to promote local structural plasticity; however, this alone does not enable much functional recovery after a spinal cord injury. In this study, the authors coupled ChABC treatment with specific motor exercises, which resulted in substantial recovery of injured rats' grasping abilities.
- Guillermo García-Alías
- Stanley Barkhuysen
- James W Fawcett
