Nature Search

KCNE1 induces fenestration in the Kv7.1/KCNE1 channel complex that allows for highly specific pharmacological targeting

Specificity of inhibitors of voltage-gated ion channels is crucial for their use as therapeutics. Here, the authors show that adamantane derivatives interact with a specific binding site on fenestrations that only become available when accessory subunits are bound to the channel.

Eva Wrobel
Ina Rothenberg
Guiscard Seebohm
ResearchOpen Access12 Oct 2016
Nature Communications

Volume: 7, P: 1-13
A common mechanism allows selective targeting of GluN2B subunit-containing N-methyl-D-aspartate receptors

Schreiber et al characterize a common inhibitory mechanism for ifenprodil and its derived compounds acting on GluN2B-containing N-methyl-D-aspartate receptors (NMDARs). These insights, generated through mutagenesis of the receptor binding site, chemical modifications of the compounds and structural modeling, may aid in the treatment of neurodegenerative diseases where GluN2B is involved.

Julian A. Schreiber
Dirk Schepmann
Guiscard Seebohm
ResearchOpen Access15 Nov 2019
Communications Biology

Volume: 2, P: 1-14
A benzodiazepine activator locks K_v7.1 channels open by electro-mechanical uncoupling

The binding site and mechanism of action for a benzodiazepine-derivative agonist on K_v7.1 channels is determined for drug development to treat long QT syndrome.

Julian A. Schreiber
Melina Möller
Guiscard Seebohm
ResearchOpen Access01 Apr 2022
Communications Biology

Volume: 5, P: 1-13
The first versatile human iPSC-based model of ectopic virus induction allows new insights in RNA-virus disease

Stefan Peischard
Huyen Tran Ho
Guiscard Seebohm
ResearchOpen Access08 Oct 2020
Scientific Reports

Volume: 10, P: 1-9
The ubiquitination landscape of the influenza A virus polymerase

Influenza A virus replication relies on host cell-derived ubiquitination of the viral polymerase. Here, Günl et al. show that site-specific ubiquitination of PB1-K578 is acquired during infection and facilitates spatiotemporal control of polymerase dimerization and NP binding.

Franziska Günl
Tim Krischuns
Linda Brunotte
ResearchOpen Access11 Feb 2023
Nature Communications

Volume: 14, P: 1-19
Cardiogenic programming of human pluripotent stem cells by dose-controlled activation of EOMES

The T-box transcription factor eomesodermin (EOMES) acts both in endoderm specification as well as heart development, suggesting context-specific function. Here, the authors show that dose-controlled EOMES induction is sufficient for cardiogenic programming of human pluripotent stem cells.

Martin J. Pfeiffer
Roberto Quaranta
Boris Greber
ResearchOpen Access30 Jan 2018
Nature Communications

Volume: 9, P: 1-8
Two-stage electro–mechanical coupling of a K_V channel in voltage-dependent activation

In voltage-gated potassium (K_V) channels, the voltage-sensing domain (VSD) undergoes activation states to trigger pore opening via electro–mechanical (E–M) coupling. Here authors show that K_V7.1 undergoes a two-stage E–M coupling mechanism during voltage-dependent activation.

Panpan Hou
Po Wei Kang
Jianmin Cui
ResearchOpen Access03 Feb 2020
Nature Communications

Volume: 11, P: 1-14
Atomic basis for therapeutic activation of neuronal potassium channels

The antiepileptic drug retigabine potentiates neuronal KCNQ potassium channels. Here, the authors use a combination of unnatural amino acid mutagenesis and electrophysiology to show that retigabine acts by hydrogen bonding with a tryptophan indole nitrogen in the channel pore.

Robin Y. Kim
Michael C. Yau
Harley T. Kurata
ResearchOpen Access03 Sept 2015
Nature Communications

Volume: 6, P: 1-11
Cloxyquin activates hTRESK by allosteric modulation of the selectivity filter

Here, the binding site of the drug cloxyquin to the TWIK-related spinal cord K+ channel (TRESK) channel is determined and it is reported that Cloxyquin activates the ion channel by allosteric stabilization of the inner selectivity filter facilitating the ion conduction process.

Julian Alexander Schreiber
Anastasia Derksen
Guiscard Seebohm
ResearchOpen Access18 Jul 2023
Communications Biology

Volume: 6, P: 1-16
Detailed analysis of Mdivi-1 effects on complex I and respiratory supercomplex assembly

Nico Marx
Nadine Ritter
Karin B. Busch
ResearchOpen Access24 Aug 2024
Scientific Reports

Volume: 14, P: 1-19
K_2P18.1 translates T cell receptor signals into thymic regulatory T cell development

Tobias Ruck
Stefanie Bock
Sven G. Meuth
ResearchOpen Access26 Oct 2021
Cell Research

Volume: 32, P: 72-88
Bioelectric-calcineurin signaling module regulates allometric growth and size of the zebrafish fin

Jacob M. Daane
Jennifer Lanni
Matthew P. Harris
ResearchOpen Access10 Jul 2018
Scientific Reports

Volume: 8, P: 1-9

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