Wang et al. analyze the metabolome and lipidome of heart and plasma samples from patients with HCM and healthy individuals and identify panels of metabolites that can be used as diagnostic biomarkers of HCM or predictors of HCM patient survival; patients are stratified into three groups with distinct cardiac function and survival and identify metabolic pathways that are greatly affected in patients with HCM, suggesting that targeting the pentose phosphate pathway and oxidative stress may represent effective ways to treat HCM.
- Wenmin Wang
- Jizheng Wang
- Zeping Hu
