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Showing 1–2 of 2 results
Advanced filters: Author: Gundula Haunschild Clear advanced filters

  • Metastatic dissemination in breast cancer patients occurs early in malignant transformation, raising questions about how disseminated cancer cells (DCC) progress at distant sites. Here, the authors show that DCCs in bone marrow are activated via IL6-trans-signaling and thereby acquire stemness traits relevant for metastasis formation.

    • Melanie Werner-Klein
    • Ana Grujovic
    • Christoph A. Klein
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-18

  • Two related papers show that cells disseminated from malignant lesions at early time points during tumorigenesis can contribute to metastases at distant organs and provide insights into the molecular basis of dissemination.

    • Hedayatollah Hosseini
    • Milan M. S. Obradović
    • Christoph A. Klein
    Research
    Nature
    Volume: 540, P: 552-558