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Turning catalytically inactive human Argonaute proteins into active slicer enzymes

Argonaute (Ago) proteins that cleave target RNAs are known as slicer enzymes. Extensive mutagenesis studies combined with in vitro cleavage assays and structural modeling have now enabled catalytically inactive human Ago1 and Ago3 to be turned into slicer enzymes, providing insight into the molecular basis of human Ago1 and Ago3 inactivity.

Judith Hauptmann
Anne Dueck
Gunter Meister
Research12 May 2013
Nature Structural & Molecular Biology

Volume: 20, P: 814-817
Proteasome subunits encoded by the major histocompatibility complex are not essential for antigen presentation

Frank Momburg
Vianney Ortiz-Navarrete
Günter J. Hämmerling
Research12 Nov 1992
Nature

Volume: 360, P: 174-177
Argonaute proteins: functional insights and emerging roles

Argonaute proteins are vital components of small-RNA-guided modes of gene regulation. Recent studies have provided important details about classical modes of Argonaute function, such as their structure and loading with small RNAs, and have also revealed unexpected roles in other cellular functions.

Gunter Meister
Reviews04 Jun 2013
Nature Reviews Genetics

Volume: 14, P: 447-459
German federal-state-wide seroprevalence study of 1^st SARS-CoV-2 pandemic wave shows importance of long-term antibody test performance

Lohse, Sternjakob-Marthaler et al. assess anti-SARS-CoV-2 antibody responses of adults in the Saarland region of Germany after the first pandemic wave. They calculate infection and fatality rates, demonstrating that SARS-Cov-2 infections during this period were underreported.

Stefan Lohse
Anna Sternjakob-Marthaler
Sigrun Smola
ResearchOpen Access18 May 2022
Communications Medicine

Volume: 2, P: 1-12

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Turning catalytically inactive human Argonaute proteins into active slicer enzymes

Proteasome subunits encoded by the major histocompatibility complex are not essential for antigen presentation

Argonaute proteins: functional insights and emerging roles

German federal-state-wide seroprevalence study of 1st SARS-CoV-2 pandemic wave shows importance of long-term antibody test performance

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German federal-state-wide seroprevalence study of 1^st SARS-CoV-2 pandemic wave shows importance of long-term antibody test performance