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Showing 1–5 of 5 results
Advanced filters: Author: Gunther Wennemuth Clear advanced filters

  • Sperm motility and male fertility requires function of the CatSper calcium channels. Here, using cryo-electron tomography, authors visualize the native in-cell 3D structure and higher-order organization of the CatSper as long zigzag rows along the sperm tail.

    • Yanhe Zhao
    • Huafeng Wang
    • Jean-Ju Chung
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • Chronic viral infections are frequently associated with the dysfunction of CD8+ T cells which includes loss of function and results in CD8+ T cell exhaustion. Here the authors show a role of CEACAM1 in promoting responsive CD8+ T cells in the context of a chronic lymphocytic choriomeningitis virus (LCMV) infection model.

    • Vishal Khairnar
    • Vikas Duhan
    • Karl S. Lang
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14

  • Gut-homing and colonization of T cells are important for maintaining local immune homoeostasis and protective immunity. Here the authors show that the kinase activity of TRPM7 regulates Th17 differentiation and T cell alloreactivity in the gut by modulating SMAD2 activation and CD103 expression in T cells

    • Andrea Romagnani
    • Valentina Vettore
    • Susanna Zierler
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-14

  • The authors find that mammalian acid-sensing taste receptor cells, previously shown to be putative sour taste sensors, also mediate responses to water. Optogenetic activation of this population of cells in thirsty mice induced robust drinking response in the absence of water. This study shows that acid-sensing TRCs contribute to the detection of water in the oral cavity.

    • Dhruv Zocchi
    • Gunther Wennemuth
    • Yuki Oka
    Research
    Nature Neuroscience
    Volume: 20, P: 927-933