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Nature Structural & Molecular Biology (2)
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Showing 1–3 of 3 results

Advanced filters: Author: Guojin Ou Clear advanced filters

Cryo-EM structure of the human subcortical maternal complex and the associated discovery of infertility-associated variants

On the basis of the assembly mechanism and structures of the human subcortical maternal complex, the authors provide a strategy for the diagnosis of reproductive disorders and the discovery of new infertility-associated SCMC variants.

Pengliang Chi
Guojin Ou
Dong Deng
Research08 Oct 2024
Nature Structural & Molecular Biology

Volume: 31, P: 1798-1807
Structural basis of the subcortical maternal complex and its implications in reproductive disorders

Here, using cryo-electron microscopy and functional assays in mouse oocytes and embryos, the authors delineate the composition of the subcortical maternal complex, showing that clinical variants associated with female reproductive diseases disrupt complex formation.

Pengliang Chi
Guojin Ou
Dong Deng
Research04 Jan 2024
Nature Structural & Molecular Biology

Volume: 31, P: 115-124
The subcortical maternal complex modulates the cell cycle during early mammalian embryogenesis via 14-3-3

The subcortical maternal complex (SCMC) maintains cleavage of early embryos. Here the authors identify 14-3-3 as a component of the SCMC and show that phosphorylation of TLE6 contributes to 14-3-3 recruitment and stabilization, ensuring mitotic entry in mouse zygotes.

Zhuo Han
Rui Wang
Dong Deng
ResearchOpen Access15 Oct 2024
Nature Communications

Volume: 15, P: 1-18